Atherosclerosis > About The Laboratory | ANZAC Research Institute Skip to content Menu Home About Us History Our Newsletter Our Facilities Collaboration Microscope and Flow Facility Research Adrenal Steroid About the Laboratory People Projects Publications Andrology About The Laboratory People Projects Publications Atherosclerosis About The Laboratory People Projects Publications Biogerontology About The Laboratory People Projects Publications Bone Biology About The Laboratory People Projects Publications Burns Research About The Laboratory People Projects Publications Cell Division About The Laboratory People Projects Publications CHAMP Project About The Laboratory People Projects Publications Dendritic Cell Research About The Laboratory People Projects Publications Neurobiology About The Laboratory People Projects Research Highlights Publications Platelets, Thrombosis and Cancer About The Laboratory People Projects Publications Vascular Biology About The Laboratory People Projects Publications News Publications Foundation Chairman’s Report Director’s Report Board Members Staff Annual Reports Contact Key Contacts Postgraduate Scholarships Summer Scholarships Donate ANZAC Research Institute +61 2 9767 9100 reception@anzac.edu.au DONATE NOW Home About Us History Our Newsletter Our Facilities Collaboration Microscope and Flow Facility Research Adrenal Steroid About the Laboratory People Projects Publications Andrology About The Laboratory People Projects Publications Atherosclerosis About The Laboratory People Projects Publications Biogerontology About The Laboratory People Projects Publications Bone Biology About The Laboratory People Projects Publications Burns Research About The Laboratory People Projects Publications Cell Division About The Laboratory People Projects Publications CHAMP Project About The Laboratory People Projects Publications Dendritic Cell Research About The Laboratory People Projects Publications Neurobiology About The Laboratory People Projects Research Highlights Publications Platelets, Thrombosis and Cancer About The Laboratory People Projects Publications Vascular Biology About The Laboratory People Projects Publications News Publications Foundation Chairman’s Report Director’s Report Board Members Staff Annual Reports Contact Key Contacts Postgraduate Scholarships Summer Scholarships Donate Atherosclerosis > About The Laboratory About People Projects Publications Atherosclerosis is a hardening and narrowing of the arteries due to the formation of atherosclerotic plaques within the vessel wall. These plaques encroach on the arterial lumen, interfering with blood flow and in acute events can rupture, blocking blood flow completely. Atherosclerosis is the underlying disease leading to a wide variety of cardiovascular related illnesses and can lead to clinical outcomes such as heart attacks or strokes when rupture occurs. Macrophages are inflammatory cells that play an important role in the initiation and the progression of the atherosclerotic plaque. Within a lesion, macrophages take up large amounts of cholesterol rendering them macrophage foam cells. These foams cells can be highly inflammatory and exacerbate lesion formation. In the Atherosclerosis Laboratory we use various cell and animal models to study macrophage foam cells, particularly: Mechanisms related to cholesterol accumulation and excretion of cholesterol from macrophage foam cells Regulatory pathways of factors secreted from macrophage foam cells Characterization of glycosylation of anti-atherogenic apolipoprotein E Cleavage of anti-atherogenic factors by macrophages (need to add) Atherosclerotic side effects of the immunosuppressant drug Cyclosporin A Role of SMPDL3A in inflammatory diseases More Information on the Atherosclerosis Research Program... About People Projects Publications About Us To provide Leadership and excellence in health and medical research activities throughout Australia, with a focus on aging, to improve the future health and medical care for the Australasian community. Read More Donate Now We need your support. Help us to continue our research by donating. DONATE NOW Contact Us +61 2 9767 9100 reception@anzac.edu.au The ANZAC Research Institute Concord Repatriation General Hospital Gate 3, Hospital Road Concord NSW 2139, Australia © Copyright 2022 ANZAC Research Institute | Privacy | Terms | Sitemap | Intranet | Design by: SB Web Designs Scroll To Top
