MRC Laboratory of Molecular Biology Skip to primary navigation Skip to main content Skip to primary sidebar MRC Laboratory of Molecular Biology One of the world's leading research institutes, our scientists are working to advance understanding of biological processes at the molecular level - providing the knowledge needed to solve key problems in human health. Search this website Home About LMB Research Research Groups Students Recruitment Life at the LMB Achievements News & Events About Us The MRC Laboratory of Molecular Biology (LMB) is a research institute dedicated to the understanding of important biological processes at the levels of atoms, molecules, cells and organisms. In doing so, we provide knowledge needed to solve key problems in human health. Our scientists tackle fundamental, often difficult and long-term research problems. The LMB has made revolutionary contributions to science, such as pioneering X-ray crystallography and electron cryo-microscopy (cryo-EM) to determine protein structures, the sequencing of DNA and the development of monoclonal antibodies. Twelve Nobel Prizes have been awarded for work carried out by LMB scientists. The LMB also promotes the application and exploitation of our research findings, both by collaboration with existing companies and the founding of new ones, helping to advance medical research and the translation and application of knowledge. The LMB provides an unsurpassed environment for both young and established researchers, with state-of-the-art facilities and a unique scientific culture. The LMB has always been very diverse, with a truly international outlook. We currently employ men and women from over 50 countries, and LMB alumni work in research organisations across the world. Insight on Research Human inner kinetochore structure reveals mechanism for binding DNA during mitosis In solving the structure of the human inner kinetochore bound to a centromeric CENP-A nucleosome, David Barford’s group in the LMB’s Structural Studies Division has revealed how the complex recognises centromeric DNA and functions as a load-bearing element during chromosome segregation. Structural study reveals unexpected diversity in GABAA receptor assembly Structural analysis of GABAA receptors by Radu Aricescu’s group, in the LMB’s Neurobiology Division, has revealed possibility for an unexpected variety in subunit arrangement, with significant implications for future research and therapeutic developments. See more Insight on Research Search Quick Links How to Find Us Current Vacancies Women in Science Seminars Contact Directory PhD Programme LMB Nobel Prizes News & Events Useful Contacts Goals and Research Focus LMB@60 LMB Exhibitions Latest News 2022 John Kendrew Lecture to be given by Alice Ting Alice Ting of Stanford University will deliver the 2022 John Kendrew lecture on ‘Chemogenetic and optogenetic technologies for probing molecular and cellular networks’. […] 160 not out: Celebrating those with 4 decades of LMB service Congratulations to David Cattermole, Pat Edwards, Paul Hart and Steve Scotcher, who have each reached 40 years of service at the LMB. […] See more News LMB in the News LMB in vitro testing highlights bicyclic peptides (Bicycle®) as potential antiviral compounds against SARS-CoV-2 LMB research featured in summary of three cryo-EM studies of TMEM106b fibrils found in neurodegenerative diseases See more LMB in the News LMB Alumni News Ruth Lehmann receives Vanderbilt Prize in Biomedical Science Sidney Altman 1939 – 2022 See more LMB Alumni News Latest Publications Differential assembly diversifies GABA receptor structures and signalling. Sente, A., et al. Nature 604(7904): 190-194. (30th April 2022) Potent TRIM21 and complement-dependent intracellular antiviral immunity requires the IgG3 hinge. Foss, S., et al. Sci Immunol 7(70): eabj1640. (29th April 2022) FCHO controls AP2's initiating role in endocytosis through a PtdIns(4,5)P-dependent switch. Zaccai, NR., et al. Sci Adv 8(17): eabn2018. (29th April 2022) Evolutionary balance between foldability and functionality of a glucose transporter. Choi, HK., et al. Nat Chem Biol [Epub ahead of print]. (28th April 2022) Reconstitution of surface lipoprotein translocation through the slam translocon. Huynh, MS., Hooda, Y., Li, YR., Jagielnicki, M., Lai, CC., Moraes, TF. Elife 11 [Epub ahead of print]. (27th April 2022) Tissue Immunity in the Bladder. Bowyer, GS., Loudon, KW., Suchanek, O., Clatworthy, MR. Annu Rev Immunol 40: 499-523. (26th April 2022) Cellular responses to halofuginone reveal a vulnerability of the GCN2 branch of the integrated stress response. Pitera, AP., Szaruga, M., Peak-Chew, SY., Wingett, SW., Bertolotti, A. EMBO J : e109985 [Epub ahead of print]. (25th April 2022) See more Publications Privacy & Cookies Contact Directory Freedom of Information Site Map Find Us ©2022 MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK. 01223 267000 The MRC is part of UK Research and Innovation Contact Us Posting....
