Rational Analysis of Coiled-Coil Packing Specificity Using the Knob-Socket Model - CORE CORE 🇺🇦 make metadata, not war Services Services overviewExplore all CORE services Access to raw data API Dataset FastSync Content discovery Recommender Discovery Managing content Repository dashboard Packages Repository edition About About us Our mission Team Blog FAQs Contact us Rational Analysis of Coiled-Coil Packing Specificity Using the Knob-Socket Model Authors Thao Nguyen Roos Nederstigt Carolyn Keim Chou Hang Publication date April 28, 2018 Publisher Scholarly Commons Abstract Identifying the interactions that exist in the leucine zipper DNA binding proteins are crucial for the understanding of disease formation, proliferation, and the development of combative measures against these diseases. Use of the Knob-Socket model for determination of packing structure provides a novel approach to analyze protein-protein as well as protein-nucleic acid interactions. A Knob-Socket analysis of the protein-protein interface provides unique insight into the classical leucine zipper pseudo-7mer repeat. A deeper analysis of longer leucine zippers shows unique packing patterns not indicated by classical representations like the helical wheel. From analysis of the Knob-Socket packing maps, this research provides evidence of a general framework for defining the specificity between coiled coils. Generally, the patterns follow classic Crick knob-into-holes packing. However, the Knob-Socket maps show how hydrophobic specificity is defined in the coiled coil interface, where knobs are centralized in the middle of the socket packing, while the peripheral socket residues are hydrophilic. Furthermore, the bias of the filled over free propensities shows a clear pattern that explains the specificity of a set of hydrophobic interactions. This research presents a clear model for the coiled-coil interaction and provides the basis for further exploration into these interactions to improve our understanding of disease formation and eventually develop techniques against these diseases text Biochemistry Similar works Full text Scholarly CommonsFull text is not available oai:scholarlycommons.pacific.edu:purcc-1205 Last time updated on 4/18/2020 This paper was published in Scholarly Commons. Having an issue? Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request. Report CORE is not-for-profit service delivered by the Open University and Jisc. Product Services Data providers Communities Terms Organisation About us Mission Team Blog Support FAQs Contact us Writing about CORE? Discover our research outputs and cite our work. COREAccessabilityCookiesPrivacy
