Socket Cells Mediate Spicule Morphogenesis in Caenorhabditis elegans Males - CORE CORE Services Services overviewExplore all CORE services Access to raw data API Dataset FastSync Content discovery Recommender Discovery Managing content Repository dashboard Packages Repository edition About About us Our mission Team Blog FAQs Contact us research10.1006/dbio.1999.9293 Socket Cells Mediate Spicule Morphogenesis in Caenorhabditis elegans Males Authors Lily I Jiang Paul W Sternberg Publication date 1999 Publisher Academic Press. Abstract AbstractCaenorhabditis elegans male spicule morphogenesis requires the coordinated cellular behaviors of several types of cells. We found that the spicule neurons and sheath cells, although important for spicule function, are dispensable for spicule morphology. In contrast, the spicule socket cells are essential for both spicule elongation and formation of spicule cuticle. The socket cells are not only necessary but also sufficient to produce spicule cuticle. This functional aspect of socket cells is genetically separable from their function in mediating spicule elongation: elongated spicules with defective spicule cuticle can be formed. During spicule morphogenesis, the expression of an egl-17::GFP reporter gene is found in the spicule socket cells and its expression appears to be regulated in the socket cells. Mutants defective in TGF-β signaling display a crumpled spicules phenotype as a result of failure of socket cell movement during spicule morphogenesis. These observations suggest that both the FGF and the TGF-β signaling pathways might be involved in spicule elongation Journal Regular Article Similar works Full text Elsevier - Publisher Connector Provided a free PDF (195.62 KB) Last time updated on May 6, 2017View original full text link This paper was published in Elsevier - Publisher Connector . Having an issue? Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request. Report Useful links Blog About CORE Contacts Cookies Privacy notice Accessibility Writing about CORE? Discover our research outputs and cite our work. CORE is a not-for-profit service delivered by The Open University and Jisc.
