Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial Toggle navigation myGriffith Staff portal Contact Us⌄ Future student enquiries 1800 677 728 Current student enquiries 1800 154 055 International enquiries +61 7 3735 6425 General enquiries 07 3735 7111 Online enquiries Staff phonebook Toggle navigation View Item Home Griffith Research Online Journal articles View Item Home Griffith Research Online Journal articles View Item JavaScript is disabled for your browser. Some features of this site may not work without it. Browse All of Griffith Research Online Communities & Collections Authors By Issue Date Titles This Collection Authors By Issue Date Titles Statistics Most Popular Items Statistics by Country Most Popular Authors Support Contact us FAQs Admin login Login Tomographic and histomorphometric evaluation of socket healing after tooth extraction using leukocyte- and platelet-rich fibrin: A randomized, single-blind, controlled clinical trial Author(s) Canellas, JVDS da Costa, RC Breves, RC de Oliveira, GP Figueredo, CMDS Fischer, RG Thole, AA Medeiros, PJDA Ritto, FG Griffith University Author(s) da Silva Figueredo, Carlos Marcelo Year published 2019 Metadata Show full item record Abstract The use of platelet concentrate in alveolar ridge preservation has been broadly studied. However, no randomized clinical trials with histomorphometric analysis and low risk of bias are available in the literature. We conducted a prospective, single-blind, parallel, randomized, controlled clinical trial to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in socket preservation after tooth extraction. Additionally, the effect of L-PRF on bone formation was analyzed histologically using bone biopsy specimens obtained during implant placement. A total of 48 subjects who underwent a non-molar tooth extraction ... View more >The use of platelet concentrate in alveolar ridge preservation has been broadly studied. However, no randomized clinical trials with histomorphometric analysis and low risk of bias are available in the literature. We conducted a prospective, single-blind, parallel, randomized, controlled clinical trial to evaluate the efficacy of leukocyte- and platelet-rich fibrin (L-PRF) in socket preservation after tooth extraction. Additionally, the effect of L-PRF on bone formation was analyzed histologically using bone biopsy specimens obtained during implant placement. A total of 48 subjects who underwent a non-molar tooth extraction were randomly assigned to the L-PRF group (n = 24) or the control group (n = 24). Cone-beam computed tomographies were performed immediately after tooth extraction and at 3 months after tooth extraction, prior to implant surgery. A significant difference in bone resorption was registered 1 mm below the crest: 0.93 ± 0.9 mm for the L-PRF group and 2.27 ± 1.2 mm for the control group (p = 0.0001). Histomorphometric analysis showed a higher percentage of new bone formation in the L-PRF group compared with the control group. The values were 55.96 ± 11.97% and 39.69 ± 11.13%, respectively (p = 0.00001). These findings indicate that the administration of L-PRF should always be considered when socket preservation is planned (Clinicaltrials.gov NCT03408418). View less > Journal Title Journal of Cranio-Maxillofacial Surgery DOI https://doi.org/10.1016/j.jcms.2019.11.006 Note This publication has been entered into Griffith Research Online as an Advanced Online Version Subject Clinical Sciences Dentistry Alveolar preservation Biopsy Bone healing Histomorphometry Platelet-rich fibrin Publication URI http://hdl.handle.net/10072/390135 Collection Journal articles Show Statistical Information Footer Disclaimer Privacy policy Copyright matters CRICOS Provider - 00233E Tagline Gold Coast Logan Brisbane - Queensland, Australia First Peoples of Australia Aboriginal Torres Strait Islander
