Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism
— University of Illinois Urbana-Champaign Skip to main navigation Skip to search Skip to main content University of Illinois Urbana-Champaign Home Help & FAQ Home Profiles Research Units Research & Scholarship Datasets Press / Media Activities Honors Search by expertise, name or affiliation Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism David T. Hughes, Barbra S. Miller, Paul B. Park, Mark S. Cohen, Gerard M. Doherty, Paul G. Gauger Research output: Contribution to journal › Article › peer-review Overview Fingerprint Abstract Background: Ongoing experience has documented equivalence of minimally invasive parathyroidectomy (MIP) and standard bilateral parathyroid exploration (BPE) for primary hyperparathyroidism in most patients; however, intraoperative conversion of MIP to BPE is required for multiple indications. This study analyzes the factors, predictors, and cure rates in converted MIP. Methods: We retrospectively analyzed a database of 1,002 patients undergoing initial parathyroidectomy for primary hyperparathyroidism from 2008 to 2011 for rate of successful MIP, converted MIP, planned BPE, and factors leading to conversion from MIP to BPE. Results: Of 989 included parathyroidectomies, 647 (65%) were successful MIP, 186 (19%) were converted MIP, and 156 (16%) were planned BPE. The most common indication for conversion included intraoperative parathyroid hormone (IOPTH) criteria not met (46%), localization incorrect (36%), and evidence of multigland disease (17%). Converted MIP had lower preoperative calcium and PTH and lower baseline IOPTH compared with successful MIP. Complication rates were similar; however, rates of persistent hyperparathyroidism were highest in converted MIPs (6%) versus planned BPEs (3%) and successful MIPs (2%; P <.01). Conclusion: Patients requiring conversion of MIP to BPE have lower preoperative serum calcium and PTH levels, a less dramatic decrease in IOPTH, and a greater rate of persistent disease than successful MIP. Original language English (US) Pages (from-to) 1428-1435 Number of pages 8 Journal Surgery (United States) Volume 154 Issue number 6 DOIs https://doi.org/10.1016/j.surg.2013.04.020 State Published - Dec 2013 Externally published Yes ASJC Scopus subject areas Surgery Online availability 10.1016/j.surg.2013.04.020 Library availabilityDiscover UIUC Full Text Related links Link to publication in Scopus Link to the citations in Scopus Fingerprint Dive into the research topics of 'Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism'. Together they form a unique fingerprint. Parathyroidectomy Medicine & Life Sciences 100% Primary Hyperparathyroidism Medicine & Life Sciences 95% Parathyroid Hormone Medicine & Life Sciences 17% Calcium Medicine & Life Sciences 7% Hyperparathyroidism Medicine & Life Sciences 6% Statistical Factor Analysis Medicine & Life Sciences 5% View full fingerprint Cite this APA Standard Harvard Vancouver Author BIBTEX RIS Hughes, D. T., Miller, B. S., Park, P. B., Cohen, M. S., Doherty, G. M., & Gauger, P. G. (2013). Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism. Surgery (United States), 154(6), 1428-1435. https://doi.org/10.1016/j.surg.2013.04.020 Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism. / Hughes, David T.; Miller, Barbra S.; Park, Paul B.; Cohen, Mark S.; Doherty, Gerard M.; Gauger, Paul G. In: Surgery (United States), Vol. 154, No. 6, 12.2013, p. 1428-1435. Research output: Contribution to journal › Article › peer-review Hughes, DT, Miller, BS, Park, PB, Cohen, MS, Doherty, GM & Gauger, PG 2013, 'Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism', Surgery (United States), vol. 154, no. 6, pp. 1428-1435. https://doi.org/10.1016/j.surg.2013.04.020 Hughes DT, Miller BS, Park PB, Cohen MS, Doherty GM, Gauger PG. Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism. Surgery (United States). 2013 Dec;154(6):1428-1435. https://doi.org/10.1016/j.surg.2013.04.020 Hughes, David T. ; Miller, Barbra S. ; Park, Paul B. ; Cohen, Mark S. ; Doherty, Gerard M. ; Gauger, Paul G. / Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism. In: Surgery (United States). 2013 ; Vol. 154, No. 6. pp. 1428-1435. @article{bdb498c411424241a71bddcc0086e7f4, title = "Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism", abstract = "Background: Ongoing experience has documented equivalence of minimally invasive parathyroidectomy (MIP) and standard bilateral parathyroid exploration (BPE) for primary hyperparathyroidism in most patients; however, intraoperative conversion of MIP to BPE is required for multiple indications. This study analyzes the factors, predictors, and cure rates in converted MIP. Methods: We retrospectively analyzed a database of 1,002 patients undergoing initial parathyroidectomy for primary hyperparathyroidism from 2008 to 2011 for rate of successful MIP, converted MIP, planned BPE, and factors leading to conversion from MIP to BPE. Results: Of 989 included parathyroidectomies, 647 (65%) were successful MIP, 186 (19%) were converted MIP, and 156 (16%) were planned BPE. The most common indication for conversion included intraoperative parathyroid hormone (IOPTH) criteria not met (46%), localization incorrect (36%), and evidence of multigland disease (17%). Converted MIP had lower preoperative calcium and PTH and lower baseline IOPTH compared with successful MIP. Complication rates were similar; however, rates of persistent hyperparathyroidism were highest in converted MIPs (6%) versus planned BPEs (3%) and successful MIPs (2%; P <.01). Conclusion: Patients requiring conversion of MIP to BPE have lower preoperative serum calcium and PTH levels, a less dramatic decrease in IOPTH, and a greater rate of persistent disease than successful MIP.", author = "Hughes, {David T.} and Miller, {Barbra S.} and Park, {Paul B.} and Cohen, {Mark S.} and Doherty, {Gerard M.} and Gauger, {Paul G.}", year = "2013", month = dec, doi = "10.1016/j.surg.2013.04.020", language = "English (US)", volume = "154", pages = "1428--1435", journal = "Surgery", issn = "0039-6060", publisher = "Mosby Inc.", number = "6", } TY - JOUR T1 - Factors in conversion from minimally invasive parathyroidectomy to bilateral parathyroid exploration for primary hyperparathyroidism AU - Hughes, David T. AU - Miller, Barbra S. AU - Park, Paul B. AU - Cohen, Mark S. AU - Doherty, Gerard M. AU - Gauger, Paul G. PY - 2013/12 Y1 - 2013/12 N2 - Background: Ongoing experience has documented equivalence of minimally invasive parathyroidectomy (MIP) and standard bilateral parathyroid exploration (BPE) for primary hyperparathyroidism in most patients; however, intraoperative conversion of MIP to BPE is required for multiple indications. This study analyzes the factors, predictors, and cure rates in converted MIP. Methods: We retrospectively analyzed a database of 1,002 patients undergoing initial parathyroidectomy for primary hyperparathyroidism from 2008 to 2011 for rate of successful MIP, converted MIP, planned BPE, and factors leading to conversion from MIP to BPE. Results: Of 989 included parathyroidectomies, 647 (65%) were successful MIP, 186 (19%) were converted MIP, and 156 (16%) were planned BPE. The most common indication for conversion included intraoperative parathyroid hormone (IOPTH) criteria not met (46%), localization incorrect (36%), and evidence of multigland disease (17%). Converted MIP had lower preoperative calcium and PTH and lower baseline IOPTH compared with successful MIP. Complication rates were similar; however, rates of persistent hyperparathyroidism were highest in converted MIPs (6%) versus planned BPEs (3%) and successful MIPs (2%; P <.01). Conclusion: Patients requiring conversion of MIP to BPE have lower preoperative serum calcium and PTH levels, a less dramatic decrease in IOPTH, and a greater rate of persistent disease than successful MIP. AB - Background: Ongoing experience has documented equivalence of minimally invasive parathyroidectomy (MIP) and standard bilateral parathyroid exploration (BPE) for primary hyperparathyroidism in most patients; however, intraoperative conversion of MIP to BPE is required for multiple indications. This study analyzes the factors, predictors, and cure rates in converted MIP. Methods: We retrospectively analyzed a database of 1,002 patients undergoing initial parathyroidectomy for primary hyperparathyroidism from 2008 to 2011 for rate of successful MIP, converted MIP, planned BPE, and factors leading to conversion from MIP to BPE. Results: Of 989 included parathyroidectomies, 647 (65%) were successful MIP, 186 (19%) were converted MIP, and 156 (16%) were planned BPE. The most common indication for conversion included intraoperative parathyroid hormone (IOPTH) criteria not met (46%), localization incorrect (36%), and evidence of multigland disease (17%). Converted MIP had lower preoperative calcium and PTH and lower baseline IOPTH compared with successful MIP. Complication rates were similar; however, rates of persistent hyperparathyroidism were highest in converted MIPs (6%) versus planned BPEs (3%) and successful MIPs (2%; P <.01). Conclusion: Patients requiring conversion of MIP to BPE have lower preoperative serum calcium and PTH levels, a less dramatic decrease in IOPTH, and a greater rate of persistent disease than successful MIP. UR - http://www.scopus.com/inward/record.url?scp=84887991378&partnerID=8YFLogxK UR - http://www.scopus.com/inward/citedby.url?scp=84887991378&partnerID=8YFLogxK U2 - 10.1016/j.surg.2013.04.020 DO - 10.1016/j.surg.2013.04.020 M3 - Article C2 - 24008086 AN - SCOPUS:84887991378 VL - 154 SP - 1428 EP - 1435 JO - Surgery JF - Surgery SN - 0039-6060 IS - 6 ER - Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2022 Elsevier B.V We use cookies to help provide and enhance our service and tailor content. By continuing you agree to the use of cookies Log in to Pure University of Illinois Urbana-Champaign data protection policy About web accessibility Contact us
