Local delivery of VEGF-Hydrogel in developing MRONJ lesion modulates socket healing and systemic cytokine response - ResearchOnline@JCU A to Z | @JCU | Current students | Staff | LearnJCU | WebMail | Library | Campus maps | Contacts ResearchOnline@JCU Depositor Login Search Browse by JCU Authors All Authors Year College/Centre Help and Information Copyright Repository Policy Statistics Contacts Local delivery of VEGF-Hydrogel in developing MRONJ lesion modulates socket healing and systemic cytokine response Sharma, Chakrabhavi Gundurao Dileep, Hamlet, Stephen, and Ivanovski, Saso (2017) Local delivery of VEGF-Hydrogel in developing MRONJ lesion modulates socket healing and systemic cytokine response. In: [Presented at the 57th Annual Scientific Meeting of the IADR ANZ Division]. 0391. From: 57th Annual Scientific Meeting of the IADR ANZ Division, 25-27 September 2017, Adelaide,SA, Australia. PDF (Abstract Only) - Published Version Restricted to Repository staff only View at Publisher Website: https://iadr.abstractarchives.com/abstra... 1 Abstract Objectives: Aetiopathogenesis of medication-related osteonecrosis of the jaw (MRONJ)was classically considered to involve direct suppression of osteoclast-induced boneremodelling and cytotoxic effects of Zoledronic acid (ZA). However, recent literaturepoints towards local and systemic suppression of angiogenesis contributing to thisprocess. Hence, this study was designed to examine the effect of locally delivered EGF-hydrogel on in situ angiogenesis and systemic cytokine response. Methods: VEGF-165 loaded hydrogel was used in ZA-induced rat MRONJ, followingextraction of maxillary molars and creation of a defect. After four weeks rats were sacrificed and gross examination and histological assessment were conducted to evaluate effect of of VEGF. Histological assessment involved quantification of osteonecrotic areas, inflammatory infiltrate otal vascularity (von Willebrand Factor, vWF immunostaining) and microvessel density (CD105). Furthermore, to assess thesystemic response induced by VEGF gel, peripheral (plasma) cytokine assay wasperformed using multiplex ELISA analysis. Item ID: 70994 Item Type: Conference Item (Abstract / Summary) Keywords: Hydrogel; Bisphosphonates; VEGF; Zoledronic acid; Angiogenesis Related URLs: Organisation Date Deposited: 29 Nov 2021 23:15 FoR Codes: 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320399 Dentistry not elsewhere classified @ 50% 32 BIOMEDICAL AND CLINICAL SCIENCES > 3203 Dentistry > 320303 Dental therapeutics, pharmacology and toxicology @ 50% SEO Codes: 20 HEALTH > 2001 Clinical health > 200102 Efficacy of medications @ 100% Downloads: Total: 1 More Statistics Actions (Repository Staff Only) Item Control Page Copyright © 1995 to , James Cook University. All rights reserved. ABN 46253211955 Member of Innovative Research Universities Feedback | Terms of use | Privacy statement | CRICOS Provider Code:00117J
