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Liz Sockett - The University of Nottingham
UK China Malaysia Main Menu Study Research Business Global About Visit A–Z Search You are here: University of NottinghamLife SciencesPeople School of Life Sciences Print Home Study with us International study Outreach Research Facilities People Our Staff Alumni News Events Contact Us Liz Sockett Professor, Faculty of Medicine & Health Sciences Download to vCard Back to the Staff Directory Personal Details Research, lab members, collaborators and news Publications Contact workRoom C15 and C27 School of Life Sciences, Medical School Queen's Medical Centre Nottingham NG7 2UH UK work0115 8230325 fax0115 8230338 liz.sockett@nottingham.ac.uk Biography BSc University of Leeds 1983; PhD University College London 1986; Research Associate, University of Illinois 1986-88; Research Associate, University of Oxford 1988-1990. Lecturer (1991-98) University of Nottingham Life Sciences. Lecturer (1998) Snr Lecturer (2001) Reader(2004) Professor (2005), University of Nottingham Institute of Genetics. Lord Dearing Award 2000, Royal Society BAAS Millennium Award 2000, Society for General Microbiology Peter Wildy Prize 2006, Daiwa-Adrian Prize for Anglo-Japanese Science 2007. University of Nottingham Student Union's Tutor Oscar 2011 and Research Supervisor Oscar 2013. Elected Fellow of the American Academy of Microbiology 2017. Elected Fellow of the Royal Society 2019. Expertise Summary Bdellovibrio predatory bacteria- molecular biology and applications. Teaching Summary I research friendly predatory bacteria as living antibiotics and so i teach microbiology . I teach on three undergraduate modules at Nottingham- all with specialisms in bacteriology. Core Skills Infection Microbiology is a first year module in Semester 1 with 205 enthusiastic freshers! - a first taste of the bacterial world! Colleagues and I offer 2 practicals and 3 lectures to begin to get you hands on with bacteria! C42418 Bacterial Genes and Development is a 2nd year module that I co teach with Dr Thorsten Allers to around 100 2nd years. We explain the intricacies and beauty of the mechanisms of gene regulation in model bacteria and in pathogens, phages and spores. C13397 Pathogens is a third year module taken by about 80 final year B.Sc students. I teach three weeks on TB, E.coli and Salmonella gut infections and the need to tackle antibiotic resistance in pathogens. My colleagues teach on malaria, schistosomes, candida and other fungal infections and on human susceptibility to infection. I organize a poster conference at which students present pathogens posters, judged by myself, my academic colleagues and their peers. I run MSci research projects on Bdellovibrio bacteria,,with the help of my lab research group. The University kindly awarded me a Lord Dearing Prize for teaching in 2000. I was awarded the Peter Wildy Prize by the UK Microbiology Society (SGM) in 2006 for communicating and teaching about microbiology. The Nottingham Student's Union kindly awarded me a "Tutor Oscar" in 2010-11 in the Category of Best All Rounder. i was chosen as one of the "100 Heroes of the Students Union" to celebrate its centenary. Research Summary Bdellovibrio bacteriovorus Our research group studies the predatory delta-Proteobacterium Bdellovibrio bacteriovorus. Bdellovibrio are tiny bacteria that naturally invade and eat the pathogenic bacteria that cause skin ulcer, burn & pressure sore infections in people, whilst not being infectious. Our long-term goals are to establish Bdellovibrio as a treatment for Gram-negative bacterial infections in humans, and in animals and plants. With our multidisciplinary approaches our lab's achievements include: The establishment of a genetic system to manipulate Bdellovibrio showing that flagellar motility, although important for locating prey, is not essential for prey-entry, but that surface pili are. Identification of a group of prey-bacterial genes that are upregulated by Bdellovibrio attack. From these genes, identification of bacterial cell wall modifications key to predation of bacteria are studied in collaboration with Dr Andrew Lovering. Establishing that predation by Bdellovibrio works on crops and animal pathogens and is safe, given orally, in animals (chickens). Establishing that Bdellovibrio predation is effective in bodily fluids including serum and begun characterising the immune response of humans to Bdellovibrio. Using a Zebrafish infection model and showing Bdellovibrio predation cures Gram-negative pathogen infections and that the host immune system contributes. In collaboration with Dr Serge Mostowy. Selected Publications KURU E, LAMBERT C, RITTICHIER J, TILL R, DUCRET A, DEROUAUX A, GRAY J, BIBOY J, VOLLMER W, VANNIEUWENHZE M, BRUN YV and SOCKETT RE, 2017. Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature microbiology. WILLIS AR, MOORE C, MAZON-MOYA M, KROKOWSKI S, LAMBERT C, TILL R, MOSTOWY S and SOCKETT RE, 2016. Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current biology. 26(24), 3343-3351 LAMBERT C, CADBY I, TILL R, SOCKETT RE and LOVERING AL, 2015. Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus Nature Communications. 6, 8884 LERNER, T.R., LOVERING, A.L., BUI, N.K., UCHIDA, K., AIZAWA, S-I., VOLLMER, W. and SOCKETT, R.E., 2012. Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness PLoS Pathogens. 8(2), e1002524 View all publications Bdellovibrio bacteriovorus Our research group studies the predatory delta-Proteobacterium Bdellovibrio bacteriovorus. Bdellovibrio are tiny bacteria that naturally invade and eat the pathogenic bacteria that cause skin ulcer, burn & pressure sore infections in people, whilst not being infectious. Our long-term goals are to establish Bdellovibrio as a treatment for Gram-negative bacterial infections in humans, and in animals and plants. With our multidisciplinary approaches our lab's achievements include: The establishment of a genetic system to manipulate Bdellovibrio showing that flagellar motility, although important for locating prey, is not essential for prey-entry, but that surface pili are. Identification of a group of prey-bacterial genes that are upregulated by Bdellovibrio attack. From these genes, identification of bacterial cell wall modifications key to predation of bacteria are studied in collaboration with Dr Andrew Lovering. Establishing that predation by Bdellovibrio works on crops and animal pathogens and is safe, given orally, in animals (chickens). Establishing that Bdellovibrio predation is effective in bodily fluids including serum and begun characterising the immune response of humans to Bdellovibrio. Using a Zebrafish infection model and showing Bdellovibrio predation cures Gram-negative pathogen infections and that the host immune system contributes. In collaboration with Dr Serge Mostowy. Current projects Mechanisms of Bacterial Invasion (Wellcome Investigator 2018-2023 Joint with Dr Andrew Lovering, University of Nottingham) Hosting Research Fellow Dr Simona Huwiler on two consecutive Swiss National Science Foundation Fellowship Projects on Exit of Bdellovibrio from Bacterial Prey. Recent Projects Mechanisms of Bdellovibrio predation (Funded by BBRSC and The Leverhulme Trust) Collaboration with Dr Stephan Schuster resulted in publication of the first genome sequence from a predatory bacterium and we determined the predatory transcriptome of genes expressed upon prey attack1. From this we have identified a range of proteins, including peptidoglycan enzymes and pilus components, that are potentially key to the predatory process, and are taking a multi-disciplinary proteomic, ultrastructural and genetic approach to understand their functions, collaborating with structural biologist Dr Andy Lovering at the University of Birmingham and Prof Waldemar Vollmer at Newcastle University. 1. http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0008599 Bdellovibrio as "living antibiotics"…… (Funded by DARPA) In response to the emergence of antimicrobial resistance as a global health issue, in addition to the development of new antibiotics, measures are being sort to identify alternatives to antibiotics. One potential approach is the use of living predatory bacteria, such as Bdellovibrio to treat infections, especially those caused by multi-drug resistant pathogens. ….In poultry. Our lab have applied whole Bdellovibrio to combat pathogens in live poultry and food crops. In collaboration with Professor John King we developed a mathematical model of Bdellovibrio predation in the presence of live decoy bacteria, of importance in establishing how Bdellovibrio could be applied as a "living antibiotic"2. In 2011 we published the first experimental trial of Bdellovibrio as an oral treatment for Salmonella in poultry, establishing activity without affecting animal wellbeing3. ….In humans? 4 We are now involved in a project to translate this to pathogens responsible for infections in humans. This is a highly multidisciplinary project, bringing together a team of researchers from microbiology, immunology, computer science and genetics to study Bdellovibrio and its actions on CDC interest pathogens using clinical isolates from the Nottingham University Hospitals NHS Trust. We are firstly testing then in zebrafish models. We are funded by DARPA, as part of their Pathogen Predators program, to investigate basic science and immunology of this predatory bacterium to underpin future human applications. This program aims to lay the groundwork for tests of a living predator-based therapeutic that we would want to establish as safe and effective against a large number of gram negative infections, including those that are resistant to conventional treatments. 2. http://aem.asm.org/content/72/10/6757.long 3. http://aem.asm.org/content/77/16/5794.long 4. http://onlinelibrary.wiley.com/doi/10.1111/1758-2229.12516/full Lab members have been actively involved in a number of initiatives and conferences relevant to our research: Specialist meetings: Small group meeting to discuss "The Current State of the Antibiotic Pipeline" hosted by The Pew Charitable Trusts, the Wellcome Trust, and the American Society for Microbiology, following publication of "A Scientific Roadmap for Antibiotic Discovery" by The Pew Charitable Trusts, May 2016 http://www.pewtrusts.org/en/research-and-analysis/reports/2016/05/a-scientific-roadmap-for-antibiotic-discovery University of Nottingham Chancellor's Lecture by Lord O'Neill, Chair of the Review on Antimicrobial Resistance http://www.nottingham.ac.uk/alumni/newseventsandfeatures/events/event-records/chancellors-lecture-series-lord-oneill.aspx Joint Programming Initiative on Antimicrobial Resistance (JPIAMR) http://www.jpiamr.eu/ Media and publications: Pew Charitable Trusts Blog: 'Outside-the-Box' Approaches Can Help Combat Antibiotic Resistance. By Carolyn Shore and Liz Sockett http://www.pewtrusts.org/en/research-and-analysis/analysis/2017/01/05/out-of-the-box-approaches-can-help-combat-antibiotic-resistance Crystal Ball 2017- Special Issue Article for Environmental Microbiology Reports Nature knows best: employing whole microbial strategies to tackle antibiotic resistant pathogens http://onlinelibrary.wiley.com/doi/10.1111/1758-2229.12518/epdf Public events: Pre-pint of Science, Nottingham, Feb 2017 Falk Forum 58 - Edinburgh. IBD - The evolution of a disease Strategy groups: Bridging the Gaps: Systems-level approaches to antimicrobial resistance http://www.nottingham.ac.uk/research/groups/bridging/ East Midlands Infectious Disease Research Network (EMIDRN) Conferences: Gordon research conference "Microbial Toxins & Pathogenicity" Gordon research conference "Bacterial Cell Surfaces" Bacterial Morphogenesis, Survival and Virulence: Regulation in 4D http://conference.iisertvm.ac.in/bmsv/index.php/welcome Zebrafish disease model society http://zdmsociety.org/zdm9/ Media news about our publications: Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae http://www.sciencedirect.com/science/article/pii/S0960982216311526 As featured on the BBC website: http://www.bbc.co.uk/news/health-38077263 and on BBC Radio 4 "Inside Science" http://www.bbc.co.uk/news/health-38106462 Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus http://www.nature.com/articles/ncomms9884 Featured on BBC Radio 4 "Inside Science" http://www.bbc.co.uk/programmes/b06s9shs and by BBSRC "How bacterial predators kill other bacteria without harming themselves" http://www.bbsrc.ac.uk/news/health/2015/151202-pr-how-bacterial-predators-kill-other-bacteria/?colour=red&issue=Winter%202016 Current Lab members Carey Lambert Rob Till Jess Tyson Paul Radford Luke Ray Simona Huwiler Emma Banks Ting Lai Callum Clark Current collaborators Dr Andrew Lovering, School of Biosciences, University of Birmingham Dr Serge Mostowy, Centre for Molecular Bacteriology and Infection, Imperial College London. Dr Mathew Diggle, Strategic & Clinical Lead for Clinical Microbiology, EMPath Pathology Services, Nottingham University Hospitals NHS Trust, Nottingham. Dr Jamie Twycross, School of Computer Science, University of Nottingham. Dr Erkin Kuru, Department of Genetics, Harvard Medical School. (Formerly Indiana University) Professor Yves Brun, Dept of Biology, Indiana University. Professor Michael VanNieuwenhze, Dept of Chemistry, Indiana University. Professor Waldemar Vollmer, Newcastle University. CADBY IT, BASFORD SM, NOTTINGHAM R, MEEK R, LOWRY R, LAMBERT C, TRIDGETT M, TILL R, AHMAD R, FUNG R, HOBLEY L, HUGHES WS, MOYNIHAN PJ, SOCKETT RE and LOVERING AL, 2019. Nucleotide signaling pathway convergence in a cAMP-sensing bacterial c-di-GMP phosphodiesterase. The EMBO journal. 38(17), e100772 MAKOWSKI Ł, TROJANOWSKI D, TILL R, LAMBERT C, LOWRY R, SOCKETT RE and ZAKRZEWSKA-CZERWIŃSKA J, 2019. Dynamics of Chromosome Replication and Its Relationship to Predatory Attack Lifestyles in Bdellovibrio bacteriovorus. Applied and environmental microbiology. 85(14), LOWRY RC, MILNER DS, AL-BAYATI AMS, LAMBERT C, FRANCIS VI, PORTER SL and SOCKETT RE, 2019. Evolutionary diversification of the RomR protein of the invasive deltaproteobacterium, Bdellovibrio bacteriovorus. Scientific reports. 9(1), 5007 RAGHUNATHAN D, RADFORD PM, GELL C, NEGUS D, MOORE C, TILL R, TIGHE PJ, WHEATLEY SP, MARTINEZ-POMARES L, SOCKETT RE and TYSON J, 2019. Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential. Scientific reports. 9(1), 4293 SLOAN TJ, TURTON JC, TYSON J, MUSGROVE A, FLEMING VM, LISTER MM, LOOSE MW, SOCKETT RE, DIGGLE M, GAME FL and JEFFCOATE W, 2019. Examining diabetic heel ulcers through an ecological lens: microbial community dynamics associated with healing and infection. Journal of medical microbiology. 68(2), 230-240 KURU, ERKIN, LAMBERT, CAREY, RITTICHIER, JONATHAN, TILL, ROB, DUCRET, ADRIEN, DEROUAUX, ADELINE, GRAY, JOE, BIBOY, JACOB, VOLLMER, WALDEMAR, VANNIEUWENHZE, MICHAEL, BRUN, YVES V. and SOCKETT, R. ELIZABETH, 2018. Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation (vol 2, pg 1648, 2017) NATURE MICROBIOLOGY. 3(2), 254-254 KURU E, LAMBERT C, RITTICHIER J, TILL R, DUCRET A, DEROUAUX A, GRAY J, BIBOY J, VOLLMER W, VANNIEUWENHZE M, BRUN YV and SOCKETT RE, 2018. Author Correction: Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature microbiology. 3(2), 254 BAKER, MICHELLE, NEGUS, DAVID, RAGHUNATHAN, DHAARINI, RADFORD, PAUL, MOORE, CHRIS, CLARK, GEMMA, DIGGLE, MATHEW, TYSON, JESS, TWYCROSS, JAMIE and SOCKETT, R. ELIZABETH, 2017. Measuring and modelling the response of Klebsiella pneumoniae KPC prey to Bdellovibrio bacteriovorus predation, in human serum and defined buffer SCIENTIFIC REPORTS. 7, TYSON, J. and SOCKETT, R. E., 2017. Predatory Bacteria: Moving from Curiosity Towards Curative TRENDS IN MICROBIOLOGY. 25(2), 90-91 KURU E, LAMBERT C, RITTICHIER J, TILL R, DUCRET A, DEROUAUX A, GRAY J, BIBOY J, VOLLMER W, VANNIEUWENHZE M, BRUN YV and SOCKETT RE, 2017. Fluorescent D-amino-acids reveal bi-cellular cell wall modifications important for Bdellovibrio bacteriovorus predation. Nature microbiology. NEGUS D, MOORE C, BAKER M, RAGHUNATHAN D, TYSON J and SOCKETT RE, 2017. Predator Versus Pathogen: How Does Predatory Bdellovibrio bacteriovorus Interface with the Challenges of Killing Gram-Negative Pathogens in a Host Setting? Annual review of microbiology. 71, 441-457 LAMBERT C, LERNER TR, BUI NK, SOMERS H, AIZAWA S, LIDDELL S, CLARK A, VOLLMER W, LOVERING AL and SOCKETT RE, 2016. Interrupting peptidoglycan deacetylation during Bdellovibrio predator-prey interaction prevents ultimate destruction of prey wall, liberating bacterial-ghosts. Scientific reports. 6, 26010 WILLIS AR, MOORE C, MAZON-MOYA M, KROKOWSKI S, LAMBERT C, TILL R, MOSTOWY S and SOCKETT RE, 2016. Injections of Predatory Bacteria Work Alongside Host Immune Cells to Treat Shigella Infection in Zebrafish Larvae. Current biology. 26(24), 3343-3351 TYSON J and SOCKETT RE, 2016. Nature knows best: employing whole microbial strategies to tackle antibiotic resistant pathogens. Environmental microbiology reports. (In Press.) LAMBERT C, CADBY I, TILL R, SOCKETT RE and LOVERING AL, 2015. Ankyrin-mediated self-protection during cell invasion by the bacterial predator Bdellovibrio bacteriovorus Nature Communications. 6, 8884 SANGWAN N, LAMBERT C, SHARMA A, GUPTA V, KHURANA P, KHURANA JP, SOCKETT RE, GILBERT JA and LAL R, 2015. Arsenic rich Himalayan hot spring metagenomics reveal genetically novel predator-prey genotypes. Environmental microbiology reports. 7(6), 812-23 MILNER DS, TILL R, CADBY I, LOVERING AL, BASFORD SM, SAXON EB, LIDDELL S, WILLIAMS LE and SOCKETT RE, 2014. Ras GTPase-like protein MglA, a controller of bacterial social-motility in Myxobacteria, has evolved to control bacterial predation by Bdellovibrio. PLoS genetics. 10(4), e1004253 SAXON EB, JACKSON RW, BHUMBRA S, SMITH T and SOCKETT RE, 2014. Bdellovibrio bacteriovorus HD100 guards against Pseudomonas tolaasii brown-blotch lesions on the surface of post-harvest Agaricus bisporus supermarket mushrooms. BMC microbiology. 14, 163 GRUNINGER RJ, THIBAULT J, CAPENESS MJ, TILL R, MOSIMANN SC, SOCKETT RE, SELINGER BL and LOVERING AL, 2014. Structural and biochemical analysis of a unique phosphatase from Bdellovibrio bacteriovorus reveals its structural and functional relationship with the protein tyrosine phosphatase class of phytase. PloS one. 9(4), e94403 CROSSMAN LC, CHEN H, CERDEÑO-TÁRRAGA A, BROOKS K, QUAIL MA, PINEIRO SA, HOBLEY L, SOCKETT RE, BENTLEY SD, PARKHILL J, WILLIAMS HN and STINE OC, 2013. A small predatory core genome in the divergent marine Bacteriovorax marinus SJ and the terrestrial Bdellovibrio bacteriovorus. The ISME journal. 7(1), 148-60 LAMBERT C and SOCKETT RE, 2013. Nucleases in Bdellovibrio bacteriovorus contribute towards efficient self-biofilm formation and eradication of preformed prey biofilms. FEMS microbiology letters. 340(2), 109-16 CAPENESS MJ, LAMBERT C, LOVERING AL, TILL R, UCHIDA K, CHAUDHURI R, ALDERWICK LJ, LEE DJ, SWARBRECK D, LIDDELL S, AIZAWA S and SOCKETT RE, 2013. Activity of Bdellovibrio hit locus proteins, Bd0108 and Bd0109, links Type IVa pilus extrusion/retraction status to prey-independent growth signalling. PloS one. 8(11), e79759 LERNER, T.R., LOVERING, A.L., BUI, N.K., UCHIDA, K., AIZAWA, S-I., VOLLMER, W. and SOCKETT, R.E., 2012. Specialized peptidoglycan hydrolases sculpt the intra-bacterial niche of predatory Bdellovibrio and increase population fitness PLoS Pathogens. 8(2), e1002524 HOBLEY, L., FUNG, R.K.Y., LAMBERT, C., HARRIS, M.A.T.S., DABHI, J.M., KING, S.S., BASFORD, S.M., UCHIDA, K., TILL, R., AHMAD, R., AIZAWA, S., GOMELSKY, M. and SOCKETT, R.E., 2012. Discrete cyclic di-GMP-dependent control of bacterial predation versus axenic growth in Bdellovibrio bacteriovorus PLoS Pathogens. 8(2), e1002493 LAMBERT C, TILL R, HOBLEY L and SOCKETT RE, 2012. Mutagenesis of RpoE-like sigma factor genes in Bdellovibrio reveals differential control of groEL and two groES genes. BMC microbiology. 12, 99 ANWARI, K., WEBB, C.T., POGGIO, S., PERRY, A.J., BELOUSOFF, M., CELIK, N., RAMM, G., LOVERING, A., SOCKETT, R.E., SMIT, J., JACOBS-WAGNER, C. and LITHGOW, T., 2012. The evolution of new lipoprotein subunits of the bacterial outer membrane BAM complex Molecular Microbiology. 84(5), 832-844 HOBLEY L, LERNER TR, WILLIAMS LE, LAMBERT C, TILL R, MILNER DS, BASFORD SM, CAPENESS MJ, FENTON AK, ATTERBURY RJ, HARRIS MATS and SOCKETT RE, 2012. Genome analysis of a simultaneously predatory and prey-independent, novel Bdellovibrio bacteriovorus from the River Tiber, supports in silico predictions of both ancient and recent lateral gene transfer from diverse bacteria. BMC genomics. 13, 670 MOREHOUSE KA, HOBLEY L, CAPENESS M, SOCKETT RE., 2011. Bdellovibrio bacteriovorus - a dedicated motorist: Three motAB stator gene products contribute to motility of a single flagellum during predatory and prey-independent growth Journal of Bacteriology. 193(4), 932 - 943. CARMEN BUTAN, LISA M. HARTNELL, ANDREW K. FENTON, DONALD BLISS, R. ELIZABETH SOCKETT, SRIRAM SUBRAMANIAM, AND JACQUELINE L. S. MILNE, 2011. Spiral architecture of the nucleoid in Bdellovibrio bacteriovorus Journal of Bacteriology. 193(6), 1341-1350 LAMBERT C, FENTON AK, HOBLEY L and SOCKETT RE, 2011. Predatory Bdellovibrio bacteria use gliding motility to scout for prey on surfaces. Journal of bacteriology. 193(12), 3139-41 LOVERING AL, CAPENESS MJ, LAMBERT C, HOBLEY L and SOCKETT RE, 2011. The structure of an unconventional HD-GYP protein from Bdellovibrio reveals the roles of conserved residues in this class of cyclic-di-GMP phosphodiesterases. mBio. 2(5), ATTERBURY, R.J., HOBLEY, L., TILL, R., LAMBERT, C., CAPENESS, M.J., LERNER, T.R., FENTON, A.K., BARROW, P. and SOCKETT, R.E., 2011. Effects of orally administered Bdellovibrio bacteriovorus on the well-being and Salmonella colonization of young chicks Applied and Environmental Microbiology. 77(16), 5794-803 CHANG C-Y., HOBLEY L., TILL R., CAPENESS M., KANNA M., BURTT W., JAGTAP P., AIZAWA S-I. and SOCKETT R.E., 2011. The Bdellovibrio bacteriovorus twin-arginine transport system has roles in predatory and prey-independent growth Microbiology. 157(11), 3079-3093 SHEN, F., HOBLEY, L., DOHERTY, N., LOH, J.T., COVER, T.L., SOCKETT, R.E., HARDIE, K.R. and ATHERTON, J.C., 2010. In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription BMC Microbiology. 10, 210 FENTON AK, LAMBERT C, WAGSTAFF PC and SOCKETT RE, 2010. Manipulating each MreB of Bdellovibrio bacteriovorus gives diverse morphological and predatory phenotypes. Journal of bacteriology. 192(5), 1299-311 FENTON, A.K., KANNA, M., WOODS, R.D., AIZAWA, S.-I. and SOCKETT, R.E., 2010. Shadowing the actions of a predator: backlit fluorescent microscopy reveals synchronous non-binary septation of predatory Bdellovibrio inside prey and exit through discrete bdelloplast pores Journal of Bacteriology. 192(24), 6329-6335 LAMBERT C, IVANOV P and SOCKETT RE, 2010. A transcriptional "Scream" early response of E. coli prey to predatory invasion by Bdellovibrio. Current microbiology. 60(6), 419-27 FENTON, ANDREW K, HOBLEY, LAURA, BUTAN, CARMEN, SUBRAMANIAM, SRIRAM and SOCKETT, RENEE E, 2010. A coiled-coil-repeat protein 'Ccrp' in Bdellovibrio bacteriovorus prevents cellular indentation, but is not essential for vibroid cell morphology. FEMS microbiology letters. 313, 89-95 LAMBERT, C., CHANG, C.-Y., CAPENESS, M.J. and SOCKETT, R.E., 2010. The first bite--profiling the predatosome in the bacterial pathogen Bdellovibrio PLoS ONE. 5(1), e8599 LAMBERT C, HOBLEY L, CHANG C, FENTON A, CAPENESS M and SOCKETT L, 2009. A predatory patchwork: membrane and surface structures of Bdellovibrio bacteriovorus. Advances in microbial physiology. 54, 313-61 SOCKETT, R.E., 2009. The Predatory Lifestyle of Bdellovibrio bacteriovorus. Annual Review of Microbiology. 63, 523-539 IIDA Y, HOBLEY L, LAMBERT C, FENTON AK, SOCKETT RE and AIZAWA S, 2009. Roles of multiple flagellins in flagellar formation and flagellar growth post bdelloplast lysis in Bdellovibrio bacteriovorus. Journal of molecular biology. 394(5), 1011-21 LAMBERT C and SOCKETT RE, 2008. Laboratory maintenance of Bdellovibrio. Current protocols in microbiology. Chapter 7, Unit 7B.2 DEPLANCHE, KEVIN, WOODS, RICHARD D, MIKHEENKO, IRYNA P, SOCKETT, R ELIZABETH and MACASKIE, LYNNE E, 2008. Manufacture of stable palladium and gold nanoparticles on native and genetically engineered flagella scaffolds. Biotechnology and bioengineering. 101(5), 873-80 ATKINSON, S., CHANG, C.-Y., PATRICK, H.L., BUCKLEY, C.M.F., WANG, Y., SOCKETT, R.E., CÁMARA, M. and WILLIAMS, P., 2008. Functional interplay between the Yersinia pseudotuberculosis YpsRI and YtbRI quorum sensing systems modulates swimming motility by controlling expression of flhDC and fliA Molecular Microbiology. 69(1), 137-151 EVANS, K.J., LAMBERT, C. and SOCKETT, R.E., 2007. Predation by Bdellovibrio bacteriovorus HD100 requires type IV pili Journal of Bacteriology. 189(13), 4850-4859 WOODS, R.D., TAKAHASHI, N., ASLAM, A., PLEASS, R.J., AIZAWA, S.-I. and SOCKETT, R.E., 2007. Bifunctional nanotube scaffolds for diverse ligands are purified simply from Escherichia coli strains coexpressing two functionalized flagellar genes Nano Letters. 7(6), 1809-1816 ATKINSON, S., SOCKETT, R.E., CAMARA, M. and WILLIAMS, P., 2006. Quorum sensing and the lifestyle of Yersinia Current Issues in Molecular Biology. 8(1), 1-10 ATKINSON, S., CHANG, C.Y., SOCKETT, R.E., CAMARA, M. and WILLIAMS, P., 2006. Quorum sensing in Yersinia enterocolitica controls swimming and swarming motility Journal of Bacteriology. 188(4), 1451-1461 HOBLEY, L., KING, J.R. and SOCKETT, R.E., 2006. Bdellovibrio predation in the presence of decoys: Three-way bacterial interactions revealed by mathematical and experimental analyses. Applied and Environmental Microbiology. 72(10), 6757-6765 LAMBERT, C., EVANS, K.J., TILL, R., HOBLEY, L., CAPENESS, M., RENDULIC, S., SCHUSTER, S.C., AIZAWA, S.-I. and SOCKETT, R.E., 2006. Characterizing the flagellar filament and the role of motility in bacterial prey-penetration by Bdellovibrio bacteriovorus Molecular Microbiology. 60(2), 274-286 WAND, M.E., SOCKETT, R.E., EVANS, K.J., DOHERTY, N., SHARP, P.M., HARDIE, K.R. and WINZER, K., 2006. Helicobacter pylori FlhB function: the FlhB C-terminal homologue HP1575 acts as a "spare part" to permit flagellar export when the HP0770 FlhBCC domain is deleted Journal of Bacteriology. 188(21), 7531-7541 LAMBERT, C., MOREHOUSE, K.A., CHANG, C.-Y. and SOCKETT, R.E., 2006. Bdellovibrio: growth and development during the predatory cycle. Current Opinion in Microbiology. 9(6), 639-644 SHARP, P.M., BAILES, E., GROCOCK, R.J., PEDEN, J.F. and SOCKETT, R.E., 2005. Variation in the strength of selected codon usage bias among bacteria Nucleic Acids Research. 33(4), 1141-1153 MOREHOUSE, K.A., GOODFELLOW, I.G. and SOCKETT, R.E., 2005. A chimeric N-terminal Escherichia coli-C-terminal Rhodobacter sphaeroides FliG rotor protein supports bidirectional E. coli flagellar rotation and chemotaxis Journal of Bacteriology. 187(5), 1695-1701 WARD, J.P., KING, J.R., KOERBER, A.J., CROFT, J.M., SOCKETT, R.E. and WILLIAMS, P., 2004. Cell-signalling repression in bacterial quorum sensing Mathematical Medicine and Biology. 21(3), 169-204 RENDULIC, S., JAGTAP, P., ROSINUS, A., EPPINGER, M., BAAR, C., LANZ, C., KELLER, H., LAMBERT, C., EVANS, K.J., GOESMANN, A., MEYER, F., SOCKETT, R.E. and SCHUSTER, S.C., 2004. A predator unmasked: life cycle of Bdellovibrio bacteriovorus from a genomic perspective Science. 303(5658), 689-692 SOCKETT, R.E. and LAMBERT, C., 2004. Bdellovibrio as therapeutic agents: a predatory renaissance? Nature Reviews: Microbiology. 2(8), 669-674 ATKINSON, S., SOCKETT, R.E., CÁMARA, M. and WILLIAMS, P., 2004. N-Acylhomoserine lactone-mediated quorum sensing in Yersinia. In: CARNIEL, E. and HINNEBUSCH, B.J., eds., Yersinia: molecular and cellular biology Wymondham: Horizon Bioscience. 75-90 KING, J.R., KOERBER, A.J., CROFT, J.M., WARD, J.P., WILLIAMS, P. and SOCKETT, R.E., 2003. Modelling host tissue degradation by extracellular bacterial pathogens Mathematical Medicine and Biology. 20(3), 227-260 WARD, J.P., KING, J.R., KOERBER, A.J., CROFT, J.M., SOCKETT, R.E. and WILLIAMS, P., 2003. Early development and quorum sensing in bacterial biofilms Journal of Mathematical Biology. 47(1), 23-55 LAMBERT, C., SMITH, M.C.M. and SOCKETT, R.E., 2003. A novel assay to monitor predator-prey interactions for Bdellovibrio bacteriovorus 109 J reveals a role for methyl-accepting chemotaxis proteins in predation Environmental Microbiology. 5(2), 127-132 KOBAYASHI, K., SAITOH, T., SHAH, D. S. H., OHNISHI, K., GOODFELLOW, I. G., SOCKETT, R. E. and AIZAWA, S.-I., 2003. Purification and Characterization of the Flagellar Basal Body of Rhodobacter sphaeroides Journal of Bacteriology. VOL 185(PART 17), 5295-5300 KOERBER, A.J., KING, J.R., WARD, J.P., WILLIAMS, P., CROFT, J.M. and SOCKETT, R.E., 2002. A mathematical model of partial-thickness burn-wound infection by Pseudomonas aeruginosa: quorum sensing and the build-up to invasion Bulletin of Mathematical Biology. 64(2), 239-260 YATES, E.A., PHILIPP, B., BUCKLEY, C., ATKINSON, S., CHHABRA, S.R., SOCKETT, R.E., GOLDNER, M., DESSAUX, Y., CAMARA, M. and SMITH, H., 2002. N-Acylhomoserine lactones undergo lactonolysis in a pH-, temperature-, and acyl chain length-dependent manner during growth of Yersinia pseudotuberculosis and Pseudomonas aeruginosa Infection and Immunity. 70(10), 5635-5646 EDWARDS, R.J., SOCKETT, R.E. and BROOKFIELD, J.FY., 2002. A simple method for genome-wide screening for advantageous insertions of mobile DNAs in Escherichia coli Current Biology. 12(10), 863-867 WARD, J.P., KING, J.R., KOERBER, A.J., WILLIAMS, P., CROFT, J.M. and SOCKETT, R.E., 2001. Mathematical modelling of quorum sensing in bacteria IMA Journal of Mathematics Applied in Medicine and Biology. 18(3), 263-292 MACKENZIE, C., CHOUDHARY, M., LARIMER, F. W., PREDKI, P. F., STILWAGEN, S., ARMITAGE, J. P., BARBER, R. D., DONOHUE, T. J., HOSLER, J. P. and NEWMAN, J. E., 2001. The home stretch, a first analysis of the nearly completed genome of Rhodobacter sphaeroides 2.4.1 Photosynthesis Research. VOL 70(PART 1), 19-41 SHAH, D. S. H., PEREHINEC, T., STEVENS, S. M., AIZAWA, S.-I. and SOCKETT, R. E., 2000. The Flagellar Filament of Rhodobacter sphaeroides: pH-Induced Polymorphic Transitions and Analysis of the fliC Gene Journal of Bacteriology. VOL 182(PART 18), 5218-5224 ASAI, Y., KAWAGISHI, I., SOCKETT, R. E. and HOMMA, M., 2000. Coupling ion specificity of chimeras between H^+- and Na^+-driven motor proteins, MotB and PomB, in Vibrio polar flagella EMBO Journal. VOL 19(PART 14), 3639-3648 MENDUM,T.A., SOCKETT,R.E. and HIRSCH,P.R., 1999. Use of molecular and isotopic techniques to monitor the response of autotrophic ammonia-oxidizing populations of the β subdivision of the class Proteobacteria in arable soils to nitrogen fertilizer Applied and Environmental Microbiology. 65(9), 4155-4162 ASAI, Y., KAWAGISHI, I., SOCKETT, R. E. and HOMMA, M., 1999. Hybrid Motor with H^+- and Na^+-Driven Components Can Rotate Vibrio Polar Flagella by Using Sodium Ions Journal of Bacteriology. VOL 181(NUMBER 20), 6332-6338 GONZALEZ-PEDRAJO, B., BALLADO, T., CAMPOS, A., SOCKETT, R. E., CAMARENA, L. and DREYFUS, G., 1997. Structural and Genetic Analysis of a Mutant of Rhodobacter sphaeroides WS8 Deficient in Hook Length Control Journal of Bacteriology. VOL 179(NUMBER 21), 6581-6588 SHAH DS, ARMITAGE JP and SOCKETT RE, 1995. Rhodobacter sphaeroides WS8 expresses a polypeptide that is similar to MotB of Escherichia coli. Journal of bacteriology. 177(10), 2929-32 SHAH DS and SOCKETT RE, 1995. Analysis of the motA flagellar motor gene from Rhodobacter sphaeroides, a bacterium with a unidirectional, stop-start flagellum. Molecular microbiology. 17(5), 961-9 BONNETT TC, COBINE P, SOCKETT RE and MCEWAN AG, 1995. Phenotypic characterisation and genetic complementation of dimethylsulfoxide respiratory mutants of Rhodobacter sphaeroides and Rhodobacter capsulatus. FEMS microbiology letters. 133(1-2), 163-8 SOCKETT, R E and ARMITAGE, J P, 1991. Isolation, characterization, and complementation of a paralyzed flagellar mutant of Rhodobacter sphaeroides WS8. Journal of Bacteriology. 173(9), 2786-90 SOCKETT RE, DONOHUE TJ, VARGA AR and KAPLAN S, 1989. Control of photosynthetic membrane assembly in Rhodobacter sphaeroides mediated by puhA and flanking sequences. Journal of bacteriology. 171(1), 436-46 SOCKETT RE, ARMITAGE JP and EVANS MC, 1987. Methylation-independent and methylation-dependent chemotaxis in Rhodobacter sphaeroides and Rhodospirillum rubrum. Journal of bacteriology. 169(12), 5808-14 ARMITAGE JP and SOCKETT RE, 1987. Sensory transduction in flagellate bacteria. Annals of the New York Academy of Sciences. 510, 9-15 School of Life Sciences University of Nottingham Medical School Queen's Medical Centre Nottingham NG7 2UH Contact us Legal information Copyright Terms and conditions Privacy Posting rules Accessibility Freedom of information Charity gateway Cookie policy Get social Connect with the University of Nottingham through social media and our blogs. Campus maps | More contact information | Jobs Browser does not support script. Browser does not support script. Browser does not support script.