Evaluation of the first maxillary molar post-extraction socket as a model for dental implant osseointegration research | QUT ePrints QUT Home Contact Home Browse About Login Evaluation of the first maxillary molar post-extraction socket as a model for dental implant osseointegration research Du, Zhibin, Lee, Ryan, Hamlet, Stephen, Doan, Nghiem, Ivanovski, Saso, & Xiao, Yin (2016) Evaluation of the first maxillary molar post-extraction socket as a model for dental implant osseointegration research. Clinical Oral Implants Research, 27(12), pp. 1469-1478. View at publisher Description OBJECTIVES: Published information regarding the use of rat jawbones for dental implant osseointegration research is limited and often inconsistent. This study assessed the suitability and feasibility of placing dental implants into the rat maxilla and to establish parameters to be used for dental implant research using this model. MATERIALS AND METHODS: Forty-two customized titanium implants (2 × 3 mm) were placed bilaterally in the maxillary first molar area of 21 Sprague-Dawley rats. Every animal received two implants. The animals were subsequently sacrificed at days 3, 7, 14, 28 and 56 post-surgery. Resin-embedded sections of the implant and surrounding maxilla were prepared for histological and histomorphometric analyses. RESULTS: The mesial root of the first molar in the rat maxilla was the optimal site to place the implant. Although the most apical 2-3 threads of the implant penetrated into the sinus cavity, 2 mm of the remaining implant was embedded in the bone. New bone formation at day 7 around the implant increased further at day 14, as measured by the percentage of bone-to-implant contact (%BIC) and new bone area (%BA) in the implant thread chambers (55.1 ± 8.9% and 63.7 ± 7.7%, respectively). There was a further significant increase between day 14 and 28 (P < 0.05), however, no significant differences were found between day 28 and 56 in either %BIC or %BA. CONCLUSIONS: The mesial root socket of the first molar in the rat maxilla is a useful model for dental implant research. Osseointegration following implant placement as measured by BIC plateaued after 28 days. The recommended implant dimensions are 1.5 mm in diameter and 2 mm in length. Impact and interest: 3 citations in Scopus 3 citations in Web of Science® Search Google Scholar™ Citation counts are sourced monthly from Scopus and Web of Science® citation databases. These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards. Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search. Notify us of incorrect data How to use citation counts More information More statistics... ID Code: 78800 Item Type: Contribution to Journal (Journal Article) Refereed: Yes Measurements or Duration: 10 Keywords: Dental implant, Maxilla, Osseointegration, Rat DOI: 10.1111/clr.12571 ISSN: 0905-7161 Pure ID: 33017524 Divisions: Current > Institutes > Institute of Health and Biomedical Innovation Current > QUT Faculties and Divisions > Science & Engineering Faculty Past > Schools > School of Chemistry, Physics & Mechanical Engineering Copyright Owner: Consult author(s) regarding copyright matters Copyright Statement: This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au Deposited On: 01 Feb 2017 05:12 Last Modified: 10 Jan 2021 15:09 Export: EndNote | Dublin Core | BibTeX Repository Staff Only: item control page Home Browse research About CRICOS No. 00213J ABN 83 791 724 622 Accessibility Copyright Disclaimer Privacy Right to Information
