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Over the past two decades, two factors have acted in concert to fuel the ascent of molecular imaging in both the laboratory and the clinic: First, an increased understanding of the molecular mechanisms of disease and second, the continued development of in vivo imaging technologies, ranging from improved detectors to novel labeling methodologies. The advent of molecular imaging has, in turn, prompted a paradigm shift in medical imaging as a whole, from its foundations in purely anatomical imaging towards techniques aimed at probing tissue phenotype and function. We have for many years exploited aberrant targets associated with cancer in order to better diagnose, stage, monitor and treat this disease. The use of Positron Emission Tomography (PET) for cancer imaging is a well-established and widely used molecular imaging modality both in clinical and research settings. Over the last 30 years, our ability to non-invasively diagnose, localize, and treat many forms of cancer has advanced tremendously. Due to their exquisite selectivity and specificity for cancer biomarkers, radiolabeled antibodies have played an important and growing role in this trend. Within the last half-decade, antibodies have emerged as enticing tools for the PET imaging of cancer and endoradiotherapy and will be the focus of this presentation. Bio Professor Jason S. Lewis is the Emily Tow Jackson Chair at Memorial Sloan Kettering Cancer Center in New York. He is the Chief Attending of the Radiochemistry & Imaging Sciences Service and serves as the Vice Chair of Research in the Department of Radiology. He holds a joint appointment in the Molecular Pharmacology Program, and he is the Director of the Radiochemistry & Molecular Imaging Probe Core in the Sloan-Kettering Institute. He also holds appointments at the Gerstner Sloan-Kettering Graduate School, New York, NY and the Weill Cornell Medical College, New York, NY. He is an Adjunct Professor in the Department of Biomedical Imaging and Image Guided Therapy, The Medical University of Vienna, Austria. Professor Lewis has served as the 2015 President of the World Molecular Imaging Society and is the President-Elect of the Society for Radiopharmaceutical Sciences. In 2014 he received a Distinguished Investigator Award from the Academy of Radiology Research and he was named a WMIS Fellow in 2015. In 2017 he was elected a Member of the International Society for Strategic Studies in Radiology and was awarded the SNMMI Michael J. Welch Award. In 2019 he was named a Fellow of the Society of Nuclear Medicine & Molecular Imaging and was awarded the SNMMI Paul C. Aebersold Award. In 2019 Professor Lewis was awarded an NCI Outstanding Investigator Award (R35). In 2020 he was awarded the ACS Bioconjugate Chemistry Lectureship Award and was named a Fellow of the Royal Society of Chemistry and the American Association for the Advancement of Science. In 2021 he was awarded the gold Medal from the World Molecular Imaging Society Lewis’ research program is a molecular imaging-based program focused on radiopharmaceutical development as well as the study of multimodality (PET, CT & MRI) small- and biomolecule-based agents and their clinical translation. He has published >300 papers and reviews in the field of radiochemistry and molecular imaging. RSVP MIPS Special Seminar March 24, 2022 12 - 1pm Zoom Yingbing Wang, MD Radiologist Massachusetts General Hospital F18 Fluoroestradiol PET imaging for breast cancer Abstract F18 Fluoroestradiol, also known as Cerianna (GE Healthcare), is an FDA approved PET radiopharmaceutical for imaging estrogen receptor positive breast cancer. This presentation will provide an overview of ER targeted imaging and a review of the preclinical and clinical data supporting its FDA approval. We will discuss the clinical applications for cancer treatment decision making and research applications for novel drug development. Bio Yingbing Wang, MD is an attending radiologist at Massachusetts General Hospital. Dr. Wang is dual boarded in diagnostic radiology and nuclear medicine. Her clinical and research focus is on oncology PET imaging. She has been the principal investigator on three prospective trials of novel PET radiotracers for imaging glioblastoma, funded by the Proton Federal Share Grant, for breast cancer, funded by Seragon/Genentech, and Multiple Myeloma funded by Dekkun Corporation. Dr. Wang is also the principal clinical investigator on an imaging trial of machine learning methods to enhance PET image quality, funded by GE Healthcare. She is the director of radionuclide therapies and program director of the Nuclear Radiology Fellowship at MGH. RSVP April 28, 2022 12 - 1pm Li Ka Shing Center, LK130 Zoom Andrei Iagaru, MD Division Chief of Nuclear Medicine and Molecular Imaging, Stanford Health Care Professor of Radiology, Stanford University Prostate Cancer beyond PSMA: Quo Vadis GRPRProstate Cancer beyond PSMA: Quo Vadis GRPR Abstract Novel radiopharmaceuticals for PET are being evaluated for the diagnosis of prostate cancer. Gastrin-releasing peptide receptor (GRPR) -targeting radiopharmaceuticals are not as widely accepted as the prostate-specific membrane antigen (PSMA)-targeting ones. However, GRPR still are a valuable class of radiopharmaceuticals even when compared with PSMA in the evaluation of prostate cancer. The presentation will provide data to support this statement. Bio Dr. Iagaru is a Professor of Radiology - Nuclear Medicine and the Chief of the Division of Nuclear Medicine and Molecular Imaging at Stanford University Medical Center. He completed medical school at Carol Davila University of Medicine, Bucharest, Romania, and an internship at Drexel University College of Medicine, Graduate Hospital, in the Department of Medicine in Philadelphia. He began his residency at the University of Southern California (USC) Keck School of Medicine, Los Angeles, in the Division of Nuclear Medicine, where he was the chief resident. Dr. Iagaru finished his residency and completed a PET/CT fellowship at Stanford University's School of Medicine in the Division of Nuclear Medicine. His research interests include PET/MRI and PET/CT for early cancer detection; clinical translation of novel PET radiopharmaceuticals; peptidebased diagnostic imaging and therapy; targeted radionuclide therapy. Over the past 14 years since joining the faculty at Stanford, Dr. Iagaru has received several awards including the Society of Nuclear Medicine (SNM) 2009 Image of the Year Award; AuntMinnie 2016 Best Radiology Image, American College of Nuclear Medicine (ACNM) Mid-Winter Conference 2010 Best Essay Award; 2009, 2014 and 2015 Western Regional SNM Scientist Award; 2011 SNM Nuclear Oncology Council Young Investigator Award; and the 2020 Sanjiv Sam Gambhir Distinguished Scientist Award, Western Regional SNM. Dr. Iagaru published more than 200 papers in peer-reviewed journals, as well as 7 book chapters and 1 book. RSVP June 23, 2022 12 - 1pm Li Ka Shing Center, LK120 Zoom Fernando Boada, PhD Associate Chair, Basic Science Translational Research, Radiology Professor of Radiology, Radiological Sciences Laboratory (RSL), Molecular Imaging Program at Stanford (MIPS), Stanford University Coming soon! Abstract Coming soon! Bio Coming soon! RSVP September 22, 2022 12 - 1pm Zoom Ali Khademhosseini, PhD, MASc CEO Terasaki Institute for Biomedical Innovation Coming soon! Abstract Coming soon! Bio Coming soon! RSVP October 27, 2022 12 - 1pm Location TBD Zoom Ying Lu, PhD, MS Professor of Biomedical Data Science and, by courtesy, of Radiology (Molecular Imaging Program at Stanford) and of Epidemiology and Population Health Stanford University Coming soon! Abstract Coming soon! Bio Coming soon! 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