The Yang Zhang Lab Home Research COVID-19 Services Publications People Teaching Job Opening News Forum Lab Only Online Services ●I-TASSER ●QUARK ●LOMETS ●COACH ●COFACTOR ●MetaGO ●MUSTER ●CEthreader ●SEGMER ●FG-MD ●ModRefiner ●REMO ●DEMO ●SPRING ●COTH ●BSpred ●ANGLOR ●EDock ●BSP-SLIM ●SAXSTER ●FUpred ●ThreaDom ●ThreaDomEx ●EvoDesign ●GPCR-I-TASSER ●MAGELLAN ●BindProf ●BindProfX ●SSIPe ●ResQ ●IonCom ●STRUM ●DAMpred ●TM-score ●TM-align ●MM-align ●RNA-align ●NW-align ●LS-align ●EDTSurf ●MVP ●MVP-Fit ●SPICKER ●HAAD ●PSSpred ●3DRobot ●MR-REX ●I-TASSER-MR ●SVMSEQ ●NeBcon ●ResPRE ●WDL-RF ●ATPbind ●DockRMSD ●DeepMSA ●FASPR ●EM-Refiner ●BioLiP ●E. coli ●GLASS ●GPCR-HGmod ●GPCR-RD ●GPCR-EXP ●Tara-3D ●TM-fold ●DECOYS ●POTENTIAL ●RW/RWplus ●EvoEF ●HPSF ●THE-DB ●ADDRESS ●Alpaca-Antibody ●CASP7 ●CASP8 ●CASP9 ●CASP10 ●CASP11 ●CASP12 ●CASP13 ●CASP14 Yang Zhang's Research Group Department of Computational Medicine and Bioinformatics Department of Biological Chemistry Medical School University of Michigan 100 Washtenaw Avenue Ann Arbor, MI 48109-2218 Phone: (734)647-1549 Fax: (734)615-6553 Email: yangzhanglabumich.edu We are interested in: Protein Structure Prediction Protein Design and Protein Engineering Structure-based Protein Function Annotation SNP Mutation and Genetic Diseases Protein-Protein Interactions Ligand Docking and Structure-Based Drug Design Determining structure and function of protein molecules is a cornerstone of modern biology and medicine. One of the main focuses of our lab is to develop computational methods to predict 3-dimensional structure of protein molecules from amino acid sequence, and to deduce the biological functions based on the sequence-to-structure-to-function paradigm. The second focus of our lab is to combine computational algorithms and biochemistry experiments to design new protein molecules with enhanced functionality beyond nature proteins. We are also working on modeling ligand-protein and protein-protein interactions, with particular interest in new drug screening targeting G protein-coupled receptors in the human genome ( >> read more ... ). Zhang Lab news: PREDICTIONCENTER.ORG (2020/12/01): I-TASSER (as Zhang-Server) and QUARK from Zhang Lab ranked at the top two positions for automated 3D structure prediction in the 14th CASP experiment; this is the 8th time of I-TASSER ranked as the top server in CASP since 2006. National Science Foundation (2020/09/17): The Zhang Lab was granted new collaborative NSF award (with Andrews, Freddolino and Young) for modeling symbiotic microbial communities. XSEDE.ORG (2020/09/16): Zhang Lab received new computing resources from NSF XSEDE (MCB160101, MCB160124 with 24 million CPU/GPU hours) for protein-folding method developments and online gateways. ( >> read more Zhang Lab news ... ) yangzhanglabumich.edu | (734) 647-1549 | 100 Washtenaw Avenue, Ann Arbor, MI 48109-2218
