Position Details Job Title: CSIRO Undergraduate Vacation Scholarships – Health & Biosecurity Reference No: 2103 Classification: CSOF1.1 Stipend: $1462.77 per fortnight Location: Please refer to the List of Projects at the end of this document Tenure: 8 to 12 weeks from November 2015 to February 2016 Role Purpose: The 2015/16 Vacation Scholarship Program is designed to provide students with the opportunity to work on real-world problems in a leading R&D organisation. Participation in the Vacation Scholarship Program has influenced previous scholarship holders in their choice of further study and future career options. Many have gone on to pursue a PhD in CSIRO or to build a successful research career within CSIRO, a university or industry. Project Description: Please refer to the list of Projects on the following pages of this document. If you require further information please contact the person listed as the contact for the project. How to Apply: Please apply for this position online at www.csiro.au/careers You will be required to: 1. select your top 2 research projects in order of preference; 2. submit a CV which includes: the reasons why the research project/s you have selected are of interest to you; and how your previous skills/knowledge and experience meets the project requirements; and an outline of your longer-term career aspirations and detail how this program will help you achieve them. 3. upload your academic results. Referees: Please ensure that your resume includes the name and contact details of your academic supervisor and at least one other referee (work or university). If you experience difficulties applying online call 1300 984 220 and someone will be able to assist you. Outside business hours please email: csiro- careers@csiro.au. Please do not email your application. Applications received via this method may not be considered. About CSIRO: The Commonwealth Scientific and Industrial Research Organisation (CSIRO) is Australia’s national science agency. At CSIRO we shape the future. We do this by using science to solve real issues. Our research makes a difference to industry, people and the planet. Project Number Health and Biosecurity Flagship - Vacation Scholarships Project Details H&B01 Project Title Are feral honeybees healthier? Project Description This project will involve collecting honeybees from feral nests and testing for several honeybee pathogen using genetic markers. Pathogen levels will be compared with those of local managed honeybees. Project Duties/Tasks Identify and collect samples from feral honeybee colonies Use genetic markers to test for honeybee pathogens Relevant Fields of Study Molecular biology Location: Black Mountain, ACT Contact: Dr John Roberts on (02) 6246 4019 or email john.roberts@csiro.au H&B02 Project Title Disease tolerance in honeybees Project Description This project will involve exposing different genetic lines of honeybees to viruses in lab assays to investigate variation in disease tolerance. Project Duties/Tasks Isolate and genetically analyse honeybee viruses Conduct lab infection assays with honeybees Relevant Fields of Study Molecular biology Location: Black Mountain, ACT Contact: Dr John Roberts on (02) 6246 4019 or email john.roberts@csiro.au H&B03 Project Title Mobile Application for Biosecurity Data Collection Project Description Effective biosecurity management relies on digitalised biosecurity data collection and management. The student is expected to develop a mobile-based application for biosecurity data collection. Project Duties/Tasks Investigate existing approaches on mobile application development Design mobile interface for biosecurity data collection Implement the mobile application Relevant Fields of Study Strong JAVA and JaveScript programming, with experience in user interface design and/or some mobile application development a plus Location: Sandy Bay, Tasmania Contact: Dr Qing Liu and via phone on (03) 6237 5698 or email Q.Liu@csiro.au H&B04 Project Title Evaluation of plant pests and pathogens impact using internet and social media metrics Project Description This project will attempt to assess whether different measures of electronic interactions can be related to actual impacts where there is data, with the aim of using them as predictors where there is no data. For example, is the nuber of web pages found on a search under the scientific name of an organism sufficient or is the common name better? Are the terms “pest” or “damage” necessary as well? Is a crop name required? Is the number of twitter threads better? Project Duties/Tasks Critically research background of using electronic statistics to assess social phenomena (Daniel Watts) and produce summary of methods and supporting evidence Research availability and reliability of data on economics of pests and pathogens on official lists (supplied), consult experts for ground truthing Continue research and produce summary Decide electronic media search sources and search strategies (what to search, what terms and what metrics (eg pages, hits, traffic, threads etc) and commence data collection Data collection; produce summary Analyse relationships between different measures of impact Write report; presentation of report and feedback Relevant Fields of Study Biology/ecology, however other disciplines considered. Location: Black Mountain, Canberra Contact: Dean Paini on (02) 6246 4178 or email Dean.Paini@csiro.au H&B05 Project Title The Digital Doctor: predict adverse drug reactions from a patient’s genome Project Description Drugs that are usually safe can cause severe adverse reactions in patients with a particular genotype. This project aims to validate genomic markers for drug toxicity in whole genome sequencing data from the 1000 genomes project. The analysis will contribute to a journal publication detailing the application of pharmacogenomics markers in Australian clinical practice. Project Duties/Tasks Compare genotype information of pharmacogenomics markers with the LD- derived exonic surrogate markers as well as imputed genotypes Summarize and visualize comparison results Contribute towards manuscript Relevant Fields of Study Bioinformatics Information Technology Biostatistics Computational Biology Location: North Ryde, Sydney NSW Contact: Denis Bauer on (02) 9325 3174 or denis.bauer@csiro.au H&B06 Project Title Tele-Medicine based clinical decision support system for sight threatening eye disease Project Description In this project, we will be developing image analysis and machine learning algorithms for early detection of eye disease such as diabetic related eye disease. The algorithms developed and properly validated will be integrated into an electronic health record system or a telemedicine system for use in the field in hospitals to screen for sight threatening eye diseases. Project Duties/Tasks Develop image processing algorithms and machine learning techniques for detection of retinal pathologies (e.g. bright lesions) related to diabetic retinopathy and other retinal diseases Validation of algorithms based on a large retinal image data set Build an end-user program which could be integrated into our Remote-l telemedicine system Relevant Fields of Study Signal processing Image processing Biomedical engineering Software engineering Location: Perth, WA Contact: Dr Di Xiao on (08) 9333 6147 or Di.Xiao@csiro.au H&B07 Project Title Mobile Health for diabetes Project Description In this project we intend to review and summarise users’ feedback on mobile apps for diabetes. The aim of this research is to identify the most important features and functions of mobile health apps from consumer’. Project Duties/Tasks To search for diabetes related mobile apps (for iOS, android, or both) and select the best ones To extract and summarise user’s feedback on the selected apps To qualitatively research the findings using content analysis and thematic mapping techniques Relevant Fields of Study Marketing Management Public Health Psychology Medicine (prior experience with qualitative research is an advantage) Location: Herston, Brisbane, Qld Contact: Farhad Fatehi on (07) 3253 3617 or farhad.fatehi@csiro.au H&B08 Project Title Identification of biomarkers associated with early identification of Alzheimer’s Disease Project Description In an effort to identify biomarkers for the early detection of Alzheimer’s Disease, the current project aims to investigate over 1000 protein markers from both Australia and overseas. Once the most informative biomarkers have been identified, graphical network analyses will be compared with Gene Ontology (G.O.) pathway information to assess their functional significance. Project Duties/Tasks Conduct feature selection analyses of biological data related to Alzheimer’s Disease Conduct graphical network analyses and compare results with G.O. pathways available online Contribute towards manuscript with results identified Relevant Fields of Study Biostatistics Mathematics Computational Biology Statistical Genetics Location: Herston, Brisbane, Qld Contact: James Doecke on (07) 3253 3697 or james.doecke@csiro.au H&B09 Project Title Enhance and optimize the performance of automatic diabetic retinopathy grading algorithm in our tele-medicine software Project Description This project will involve improving our image processing routines that analyse retinal images. The student will work on optimizing the algorthyms within our tele-medicine system to reduce the time it takes in processing the images and providing initial grading to our clinical users. Project Duties/Tasks Investigate the use of various computer science techniques in the existing software, including parallel processing and multi-threading (e.g. using boost/openMP) Utilising GPU for faster image processing (e.g. using CUDA libraries) Work with our tele-medicine platform (Remote-l) to integrate the new grading algorithm Re-write existing C++ code in Python Time permitting we will also investigate the use of cloud computing platforms such as Google’s or Amazon to investigate potential to move the grading to a cloud based system Relevant Fields of Study Signal processing Image processing Biomedical engineering Software engineering Location: Floreat, WA Contact: Janardhan Vignarajan on (08) 9333 6132 or janardhan.vignarajan@csiro.au H&B10 Project Title Early identification of need for surgery for Crohn’s Disease Project Description Investigate the magnetic resonance enterology (MRE) biomarkers from participants with Crohn’s disease to identify markers of inflammation that associated with surgery. Using a combination of clinical phenotype information with the MRE data, the project aims to identify those individuals that are at risk of needing surgery so that early intervention maybe provides as an alternative. Project Duties/Tasks Identify those MRE biomarkers that are associated with inflammation leading to surgery In addition to the MRE markers, find associated clinical phenotype markers that are also predictive of surgery Write a report from work conducted that will be used to contribute to a journal publication Relevant Fields of Study Biostatistics Mathematics Medical science Medical imaging Location: Herston, Brisbane, Qld Contact: Jason Dowling on (07) 3253 3634 or jason.dowling@csiro.au H&B11 Project Title CSIRO Health Diet Score Project Description The CSIRO Healthy Diet Score allows Australians to measure the quality of their eating habits using a simple online assessment tool. This project will see the development of the next generation tool for the CSIRO healthy diet score. The project will produce a mobile app that will use of smart phone features to gather information and will provide users with recommendations for products that will help them to improve their health. Project Duties/Tasks Work with domain experts to develop requirements including novel food recall techniques Develop mobile prototype (iOS/Android/HTML5) Conduct user testing Relevant Fields of Study Computer science Computer engineering Location: Marsfield, NSW Contact: Jill Freyne on 02 9372 4453 or email jill.freyne@csiro.au H&B12 Project Title Health indicator for grocery shopping Project Description This project will develop a persuasive tool to help shoppers understand their grocery shopping. The tool will combine purchase data with nutrition information to raise awareness of the food choices. The candidate would work with technical, behavioural science and nutrition experts to design and develop the tool. Project Duties/Tasks Work with domain experts to develop requirements Develop mobile or web prototype Conduct user testing Relevant Fields of Study Computer science Computer engineering Location: Marsfield, NSW Contact: Shlomo Berkovsky on 02 9372 4235 or email shlomo.berkovsky@csiro.au H&B13 Project Title Foetal Brain Development – 3D MRI reconstruction and analysis Project Description Fast Magnetic Resonance Imaging (MRI) sequences enables acquiring stacks of 2D images of the foetus in-utero. However, because of the constant foetal motion, random displacement occurs in-between images, and reconstructing an accurate 3D volume for quantitative evaluation is challenging. Novel super-resolution techniques combine N stacks of low resolution MRIs and remove the effect of random displacements to produce a motion free high-resolution 3D reconstruction. This project will involve building a reliable 3D foetal imaging workflow that is useful for our clinical partners. Project Duties/Tasks Building a reliable 3D foetal imaging reconstruction workflow using recent open source and in-house software tools (C++ or Bash or Python) Adapting, optimizing or writing new software modules to adapt the reconstruction method to the images provided by our clinical partners (C++ and/or CUDA) Analyse the accuracy of the proposed solution Relevant Fields of Study Medical physics Computer science Software engineering Biomedical engineering Location: Herston, Brisbane, Qld Contact: Jurgen Fripp on (07) 3253 3660 or email jurgen.fripp@csiro.au H&B14 Project Title Neuroimaging Analysis and Executive Functions Project Description This project will examine the relationship between behavioural presentations of three syndromes characterized by executive dysfunction (disinhibited, apathetic and dysexecutive) and functional neuroimaging measures using the resting state FDG-PET amongst older adults. The vacation scholar will learn about the analysis of the neuroimaging data, and the administration, scoring and interpretation of neuropsychological tests. Project Duties/Tasks Data collection and involvement in the neuropsychological tests Developing the current statistical analysis platform in R/python/C++ Analysing the correlation between neuroimaging and psychometric data Documentation, preparation of scientific/technical report, or an conference abstract Relevant Fields of Study Computer science Electrical engineering Mathematics Statistics Psychology Neuroscience Location: Hollywood Private Hospital (Offsite, WA) Contact: Kaikai Shen (08) 6298 6313 or email Kaikai.Shen@csiro.au H&B15 Project Title Neuroimaging Analysis at Ultra High Fields Project Description This project will involve developing software and analysis techniques to segment the brain and calculate the thickness of the cortex from very high resolution MR data acquired at the University of Queensland on their new 7T MRI scanner. In addition, the project will extract myelin and T2* surface maps of the brain. Project Duties/Tasks Customize and extend MilxView’s C++ neuroimaging software to accurately segment and calculate cortical thickness from very high resolution MR data. Support anatomist in performing manual analysis and validation of software. Write technical report on results. Relevant Fields of Study Computer science Electrical engineering Mathematics Location: Herston, Brisbane, Qld Contact: Kaikai Shen (08) 6298 6313 or email Kaikai.Shen@csiro.au H&B16 Project Title SunLite: promoting the awareness of UV exposure using wearable technologies Project Description Understanding the impact of ultraviolet (UV) exposure on the healthy body can help people to decrease the risks of sunburn and skin cancer. This project focuses on the use of wearable technologies for the design of persuasive interventions to make people aware of their UV exposure and provide them with tailored protection guidelines. Project Duties/Tasks Study and evaluate commercial wearable UV ray monitoring devices (API, logging, communication, battery life, etc) Develop an application for recording UV exposure using the selected wearable technology and collecting essential user data Design and implement several graphical visualisation (charts, diagrams, etc) of the UV exposure user data Implement tailored persuasive interventions (alerts, text messages, etc) for increasing user awareness of their UV exposure levels. Relevant Fields of Study Computer science Information technology Human computer interaction Location: Marsfield, NSW Contact: Shlomo Berkovsky: (02) 9372 4253 or shlomo.berkovsky@csiro.au Sazzad Hussain: (02) 9372 4177 or sazzad.hussain@csiro.au H&B17 Project Title Beating the state-of-the-art in medical concept recognition using Deep Learning Project Description Health data repositories often contain valuable information stored in free text which is unstructured and ambiguous. This project will investigate if Deep Learning, a new trend in Artificial Intelligence that uses neural networks that are several layers deep, can be used to improve the performance of current state-of-the-art Natural Language Processing techniques that are used to identify medical concepts in free text. Project Duties/Tasks The project will be divided into five phases: Understanding the state of the art (2 weeks): The student will look at key papers that explain the state of the art in concept identification from medical text. Preparing the evaluation framework (3 weeks): It is important to have a framework in place to quickly evaluate new methods on a wide range of test collections. In this task the student will help with the design and implementation of a testing framework that uses several test corpora. Replicating state-of-the-art results (1 week): Using the evaluation framework, the student will replicate some of the well-known concept identification techniques. Designing a Deep Learning approach for the concept identification task (5 weeks): This is the core task of the project. The student will design and implement a deep learning approach to concept identification in medical text. Evaluating the Deep Learning approach (1 week): Using the evaluation framework, the student will compare the performance of the deep learning solution against other state-of-the-art techniques. Relevant Fields of Study Computer Science, Information Technology and related disciplines. Skills/Knowledge required: Java, algorithm development, machine learning; and at least one of following desirable skills/knowledge: Natural language processing, neural networks, deep learning Location: Herston, Brisbane, Qld Contact: Alejandro Metke on (07) 3253 3645 or email alejandro.metke@csiro.au H&B18 Project Title Automated Classification of Queries to a Medical Search Engine Project Description Our team is developing a search engine specifically designed for medical/clinical data. Specifically, this student project will look at applying machine learning methods to better categorise clinical search queries into different types (diseases, treatments, test, etc.) and then utilise these categories to improve search results. Project Duties/Tasks Collate a dataset of clinical queries and their categories Develop statistical machine learning classifiers (e.g., Support Vector Machines) to classify data of clinical queries Evaluate the effectiveness of the classifiers Integrate the classifier within an existing clinical search engine Relevant Fields of Study Computer science / software engineering / I.T. The project involves following skills: Good programming skills (preferable in Java, Python or C++) Knowledge of algorithms, data structures Natural language processing Some statistics experience Location: Herston, Brisbane Qld Contact: Dr Bevan Koopman on (07) 3253 3635 or bevan.koopman@csiro.au H&B19 Project Title A Scenario Specific Medical Search Engine Project Description Our team is developing a search engine specifically designed for medical/clinical data. Specifically, this student project will adapt search results according different clinical scenarios – diseases, treatments, tests, etc. Project Duties/Tasks Setup the a search engine and index a collection of medical records Divide the medical records according to mentions of different scenarios – diseases, treatments, tests, etc. Adapt the search engine ranking mechanism to favour specific scenarios Evaluate the effectiveness of different scenario specific rankings. Relevant Fields of Study Computer science / software engineering / I.T. The project involves following skills: Good programming skills (preferable in Java, Python or C++) Knowledge of algorithms, data structures Natural language processing Some statistics experience Location: Herston, Brisbane Qld Contact: Dr Bevan Koopman on (07) 3253 3635 or bevan.koopman@csiro.au H&B20 Project Title Visualising Medical Search Engine Results Project Description Our team is developing a search engine specifically designed for medical/clinical data. Specifically, this student project will extract different clinical scenarios – diseases, treatments, tests, etc. – from search engine results and present those in a visual, interactive search results UI. Project Duties/Tasks Setup the ElasticSearch search engine and index a collection of medical records Divide the medical records according to mentions of different scenarios – diseases, treatments, tests, etc. – and index these separately Extend the basic search engine results to include interactive plots and visualisations providing summaries of the different clinical scenarios Relevant Fields of Study Computer science / software engineering / I.T. The project involves following skills: Good programming skills (preferable in Java, Python or C++) Front-end web UI skills Web services, including REST, JSON, etc. Location: Herston, Brisbane Qld Contact: Dr Bevan Koopman on (07) 3253 3635 or bevan.koopman@csiro.au